Hu Li, PhD

Hu Li, PhD is a Professor of Systems Pharmacology at Mayo Clinic Rochester and serves as MPI on the CLEAR-AD U19 Analytics Core. He is a scientist with groundbreaking contributions in Systems Biology and Pharmacology in Alzheimer’s disease (AD), aging, stem cell and cancer.  Dr. Li is focused in developing innovative computational tools inspired in systems biology and pharmacology, that are critical for the development of individualized systems medicine in Alzheimer’s disease.

His team at Mayo Clinic has developed many systems biology network tools, including NetDecoder, P-Map, MALANI, EDDI, RSI, PERMUTOR and ANNE. Li’s team is actively developing novel network tools and harnessing artificial intelligence (AI) and machine learning (ML) methods to study context-dependent activities of regulatory networks at genome-wide scale as well as their spatial regulation. These and other computational platforms under development can greatly illuminate the understanding of disease mechanisms underlying drugs’ modes of action, addressing key challenges in Big Data-oriented biomedical complex systems and will ultimately lead to precision medicine for each Alzheimer patient.

Dr. Li’s team is highly collaborative and their contributions using systems biology’s methodologies span from Alzheimer’s disease and neurodegenerative conditions to aging, senescence, cellular reprogramming and engineering, cancers, and COVID-19.